Friday, March 6, 2015

Which antidepressant medications carry the highest risk for suicide and self-harm?


Which antidepressant medications carry the highest risk for 
suicide and self-harm?

In patients with clinical depression, rates of suicide and self-harm are similar among those treated with selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, but higher among those treated with other antidepressants.

This is a large study but the data is far from solid. There were a small number of events and there were differences in how all these medications were prescribed. If one type of medication was prescribed more often to patients with more severe depression, then the increased suicide risk with the use of this type of medication would relate to the severity of the depression treated and not to an effect of the medication. The most important message in this article is that it showed the increased rate of suicide occurs in the first 28 days after starting an antidepressant medication and in the 28 days after stopping the medication, these are the times when we have to increase the vigilance for suicidal ideations. 

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